Inhibitory Effect of Rhodomyrtus tomentosa Methanolic Leaves Extract on P-selectin Platelet Aggregation of ABO Blood Group by ELISA Method

Evana Kamarudin, Nur Fadhillah Megat Ismail, Siti Norul Fatin Ismail


In light of discovering the new antiplatelet from the natural source, this study was undertaken to determine the inhibitory effect of Rhodomyrtus tomentosa methanolic leaves extracts on P-selectin platelet aggregation of the ABO blood group. Whole blood samples from each blood group were collected tested with different concentration of leaves extract by using ELISA method. The inhibition was considered to occur if the values of concentration P selectin detected below 1.56 ng/ml. Instead of inhibiting the P-selectin expression as antiplatelet, Rhodomyrtus tomentosa accelerates the P-selectin expression as an agonist in a dose-dependent manner. In conclusion, no antiplatelet effects were seen.

Keywords: P-selectin, Rhodomyrtus tomentosa, platelet aggregation, ABO Blood Group

eISSN: 2398-4287© 2019. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license ( Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, UniversitiTeknologi MARA, Malaysia.

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