Kinetic Study of Natural Anticancer Drug (Zerumbone) Release from Zeolite Y-Gelatin Hybrid for Oral Controlled Delivery

Rosmamuhamadani Ramli; Norashikin Salleh; Mohd Muzamir Mahat; Sabrina M Yahaya

doi:10.21834/e-bpj.v9iSI17.5441

Authors

Rosmamuhamadani Ramli Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Norashikin Salleh Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Mohd Muzamir Mahat Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Sabrina M Yahaya Applied Chemistry Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

DOI:

https://doi.org/10.21834/e-bpj.v9iSI17.5441

Keywords:

Kinetic Study , Oral Controlled Release , Zeolite Y , Zerumbone

Abstract

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

References

Abdul, A.B.H., Al-Zubairi, A.S., Tailan, N.D., Wahab, S.I.A., Zain,Z., Ruslay, N.M., & Syam. S. (2008). Anticancer Activity of Natural Compound (Zerumbone Extracted from Zingiber zerumbet in Human HeLa Cervical Cancer Cells). Int Journal of Pharmacology 4, 160–168. DOI: https://doi.org/10.3923/ijp.2008.160.168

Aljunid,S.M., Zafar,A., Saperi, S. (2010). Burden of disease associated with cervical cancer in Malaysia and potential costs and consequences of HPV vaccination. Asian Pac J Cancer Prev, 11(6), 1551-1559.

Cervical Cancer, Human Papillomavirus (HPV), and HPV Vaccines. WHO. World Health Organization (2017).

Chabner, B.A. and Jr. Robert. T.G. (2005). Timeline: Chemotherapy and the war on cancer. Nat.Rev. Cancer, 65-72 DOI: https://doi.org/10.1038/nrc1529

Datt, A. Applications of mesoporous silica and zeolites for drug delivery. University of Iowa (2012).

Migneault, I., Dartiguenave, C., Bertrand, M.J., & Waldron, K.C. (2004). Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking. BioTechniques, 37, 790-802. DOI: https://doi.org/10.2144/04375RV01

Mukarami, A., Daisuke, T., Takashi, K., Koichi, K., Kim, H.W….Hajime, O. (2002). Zerumbone, a southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the αβ-unsaturated carbonyl group is a prerequisite. Carcinogenesis, 23(5), 795-802. DOI: https://doi.org/10.1093/carcin/23.5.795

Nichols, J.W., & Bae, Y.H. (2014). EPR: Evidence and fallacy. Journal of Controlled Release, 190, 451-464. DOI: https://doi.org/10.1016/j.jconrel.2014.03.057

Rahman, H.A., Rasedee, A., Yeap, S.K., Othman, H.H., Chart and M.S. (2014). Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. Bio Med. Res. Int. DOI: https://doi.org/10.1155/2014/920742

Rayan, A., Raiyn, J., and Falah, J. (2017). Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity. PLoS ONE, 12(11), 1-14. DOI: https://doi.org/10.1371/journal.pone.0187925

Ribeiro, L., Alcântara, N.M., Ana, C.S., Rodrigues Da Silva., Gustavo, H., … Michelle, F.M. (2017). Advances in Hybrid Polymer-Based Materials for Sustained Drug Release. International Journal of Polymer Science. 16 DOI: https://doi.org/10.1155/2017/1231464

Salazar, H, Lima, A.C., Lopes, A.C., Botelho, G., Lanceros-Mendez, S. (2015). Poly (vinylidene fluoride-trifluoromethyl)/NAY zeolite hybrid membranes as drug release platform applied to ibuprofen release. Colloids Surf a Physicochem Eng Asp, 469, 93-99. DOI: https://doi.org/10.1016/j.colsurfa.2014.12.064

Santoro, M., & Tatara, A.M. (2014). Gelatin carriers for drug and cell delivery in tissue engineering. J Controlled Release, 190. DOI: https://doi.org/10.1016/j.jconrel.2014.04.014

Shanthi, V., Majdah, M., Syed Aljunid et al. (2012). Cervical cancer in Malaysia: can we improve our screening and preventive practice? BMC Public Health. 12(2), 17. DOI: https://doi.org/10.1186/1471-2458-12-S2-A17

Singh, S., Bhupender, S., Kanwar, S.S., Kumar. A. (2016). Lead phytochemicals for anticancer drug development. Front Plant Sci, 7, 1667. DOI: https://doi.org/10.3389/fpls.2016.01667

Weaver, B.A. (2014). How taxol/paclitaxel kills cancer cells. Mol Biol Cell. 25(18), 2677-2681. DOI: https://doi.org/10.1091/mbc.e14-04-0916

Wen, H., & Park, K. (2010). Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice (pp. 245–256) John Wiley & Sons. DOI: https://doi.org/10.1002/9780470640487

Workman. P. (2005). New cancer drugs are on the horizon. Future Oncol, 1(3), 315-318. DOI: https://doi.org/10.1517/14796694.1.3.315

Zaridah, S. (2014). A Review of Cervical Cancer Research in Malaysia, J. Malaysia, 69.

Zhang, Y.C., Leong, H.F., & Kam, W. (2013). Advanced materials and processing for drug delivery: The past and the future. Advanced Drug Delivery Reviews, 65(1), 104-120. DOI: https://doi.org/10.1016/j.addr.2012.10.003