Patient Beliefs and Motivations for Adopting Biologically-based Therapies in Thalassemia Management in Malaysia

Wan ismahanisa Ismail; Nurdiana Zainuddin; Rusnani Ab Latif; Dwi Wahyu Idriati

doi:10.21834/e-bpj.v10iSI35.7512

Authors

Wan ismahanisa Ismail Faculty of Health Sciences Universiti Teknologi MARA, Penang, Malaysia, 13200 Kepala Batas , Penang, Malaysia; Health Science Faculty, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia; Division of Medical Laboratory Technology , Department of Health , Faculty of Vocational Studies, Universitas Airlangga Surabaya , Indonesia
Nurdiana Zainuddin Faculty of Health Sciences Universiti Teknologi MARA, Penang, Malaysia, 13200 Kepala Batas , Penang, Malaysia
Rusnani Ab Latif Faculty of Health Sciences Universiti Teknologi MARA, Penang, Malaysia, 13200 Kepala Batas , Penang, Malaysia
Dwi Wahyu Idriati Division of Medical Laboratory Technology , Department of Health , Faculty of Vocational Studies, Universitas Airlangga Surabaya , Indonesia

DOI:

https://doi.org/10.21834/e-bpj.v10iSI35.7512

Keywords:

Thalassemia, Biologically-based Therapies, Patient Beliefs

Abstract

Herbs, vitamins, and supplements mitigate chronic conditions like thalassaemia, a genetic blood disorder that compromises mental and physical health. These rituals are prevalent; yet, the reasons of Malaysian thalassaemia patients remain ambiguous. We evaluated healthcare accessibility, motivations, perceived benefits, and the interactions between physicians and nurses among 390 individuals in Northern Malaysia. The figures indicate that individuals employ it for its health benefits, cultural beliefs, and preference for traditional remedies. Patients rarely engage in communication with clinicians. Healthcare providers and patients must understand each other's cultural situations.

References

Al-Waili, N. S. (2003). Effects of Daily Consumption of Honey Solution on Hematological Indices and Blood Levels of Minerals and Enzymes in Normal Individuals. Journal of Medicinal Food, 6(2), 135–140. https://doi.org/10.1089/109662003322233549

Abdul Wahab, F., Abdul Halim, N. H., Ahmad, K., & Ismail, E. (2011). Use of complementary and alternative medicine among patients with thalassemia in Malaysia. Singapore Medical Journal, 52(11), 835–838.

Cappellini, M. D., Cohen, A., Piga, A., Bejaoui, M., Perrotta, S., Agaoglu, L., Aydinok, Y., Kattamis, A., Kilinc, Y., Porter, J., & Vichinsky, E. (2008). A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood, 107(9), 3455–3462. https://doi.org/10.1182/blood-2005-08-3430

Carvalho, M. C., Barata, A. J. B., Silva, M. R., & Garrido, C. E. (2001). Iron overload in patients with beta-thalassemia major: Iron chelation therapy and dietary iron intake. Revista Portuguesa de Cardiologia, 20(7–8), 759–777.

Dhanoa, A., Yong, T. L., Yeap, S. S., Lee, B. C., & Singh, S. (2014). Complementary and alternative medicine use among Asian patients with rheumatic diseases. Journal of Clinical Rheumatology, 20(2), 108–112. https://doi.org/10.1097/RHU.0000000000000078

Efe, E., Taşcı, S., & Elmali, F. (2013). Use of complementary and alternative medicine by parents of children with thalassemia in eastern Turkey. International Journal of Hematology and Oncology, 23(3), 167–172.

El Sayed, A. M., Abo El-Magd, N. F., & Abd El Aziz, S. A. (2014). The protective role of honey against lead acetate–induced hepatotoxicity and nephrotoxicity in Swiss albino mice. Biological Trace Element Research, 160, 87–94. https://doi.org/10.1007/s12011-014-0035-0

Fugh-Berman, A. (2000). Herb-drug interactions. The Lancet, 355(9198), 134–138. https://doi.org/10.1016/S0140-6736(99)06415-0

İncedayı, B., Onal, S., & Ozcan, M. M. (2010). Physico-chemical properties, antioxidant activities and mineral content of pomegranate (Punica granatum L.) juice. Journal of Food, Agriculture & Environment, 8(2), 95–98.

Lee, W. S., Ng, D. L., & Kaur, P. (2011). Non-compliance with iron chelation therapy in patients with transfusion-dependent thalassaemia: A common and important issue. Malaysian Journal of Paediatrics and Child Health, 17(1), 25–32.

Ngoo, K. S., Lim, C. S., & Tan, T. C. (2018). Complementary and alternative medicine use among patients with transfusion-dependent thalassemia in Malaysia: A cross-sectional survey. Archives of Pharmacy Practice, 9(4), 63–68.

Phang, H. P., Lee, J., Loh, C. Y., & Chin, M. (2021). Understanding concerns and experiences of thalassaemia patients, carriers, and caregivers: A qualitative study in Malaysia. International Journal of Environmental Research and Public Health, 18(15), 8021. https://doi.org/10.3390/ijerph18158021

Wong, L. P., George, E., Tan, J. A. M. A., & Mastura, M. Y. (2021). Economic burden of transfusion-dependent thalassemia in Malaysia from the provider and societal perspectives. Orphanet Journal of Rare Diseases, 16, Article 428. https://doi.org/10.1186/s13023-021-01791-8

Miller, L. G. (1998). Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Archives of Internal Medicine, 158(20), 2200–2211. https://doi.org/10.1001/archinte.158.20.2200

Rashidi, A., & Ghafari, H. (2011). Vitamin E and oxidative stress: An overview. Archives of Iranian Medicine, 14(6), 343–346.