Oxytocin Levels and Postnatal Depression among Asian Postpartum Mothers: A scoping review

Norhaini Majid; Fatimah Sham; Zamzaliza Abdul Mulud; Uliyatul Laili

doi:10.21834/e-bpj.v10i33.7269

Authors

Norhaini Majid Centre for Nursing Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia
Fatimah Sham Centre for Nursing Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia
Zamzaliza Abdul Mulud Centre for Nursing Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Malaysia
Uliyatul Laili Fakultas Keperawatan Dan Kebidanan Universitas Nahdlatul Ulama, Surabaya, Indonesia

DOI:

https://doi.org/10.21834/e-bpj.v10i33.7269

Abstract

The depression among postpartum mothers has been discussed related to the changes in oxytocin level that would affect the mental health of mothers after childbirth. The review investigated the oxytocin level and postnatal depression among mothers to understand the relationship between oxytocin levels and postnatal depression among postpartum mothers in Asian countries from the existing literature. The selected literature followed the PRISMA framework for identifying, screening, and selecting relevant studies from three databases featuring PubMed, Scopus and Web of Science with 303 studies. A total of nine studies were assessed for eligibility and included in this final review after the literature.

Keywords: Oxytocin level; depression; postpartum mothers

References

Abulaiti, A., Abudurexiti, M., Nuermaimaiti, A., & Kelimu, A. (2022). Analysis of the incidence and influencing factors of postpartum depression and anxiety: A cross-sectional study in Xinjiang from 2018 to 2021. Journal of Affective Disorders, 302, 15–24. DOI: https://doi.org/10.1016/j.jad.2022.01.069

Banasiewicz, J., Zaręba, K., Bińkowska, M., Rozenek, H., Wójtowicz, S., & Jakiel, G. (2020). Perinatal predictors of postpartum depression: Results of a retrospective comparative study. Journal of Clinical Medicine, 9(9), 2952. DOI: https://doi.org/10.3390/jcm9092952

Bradshaw, H., Riddle, J. N., Salimgaraev, R., Zhaunova, L., & Payne, J. L. (2022). Risk factors associated with postpartum depressive symptoms: A multinational study. Journal of Affective Disorders, 301, 345–351. DOI: https://doi.org/10.1016/j.jad.2021.12.121

Cevik, A., & Alan, S. (2021). Are pregnancy and postpartum oxytocin levels a predictive biomarker for postpartum depression? Journal of Obstetrics and Gynaecology Research, 47(12), 4280–4288. DOI: https://doi.org/10.1111/jog.15023

Chen, Q., Zhuang, J., Zuo, R., Zheng, H., Dang, J., & Wang, Z. (2022). Exploring associations between postpartum depression and oxytocin levels in cerebrospinal fluid, plasma, and saliva. Journal of Affective Disorders, 315, 198–205. DOI: https://doi.org/10.1016/j.jad.2022.07.052

Huang, C., Fan, Y., & Hu, S. (2023). The prevalence and influencing factors of postpartum depression between primiparous and secundiparous. The Journal of Nervous and Mental Disease, 211(3), 190–194. DOI: https://doi.org/10.1097/NMD.0000000000001591

Johansen, S. L., Stenhaug, B. A., Robakis, T. K., Williams, K. E., & Cullen, M. R. (2020). Past psychiatric conditions as risk factors for postpartum depression: A nationwide cohort study. The Journal of Clinical Psychiatry, 81(1), 18405. DOI: https://doi.org/10.4088/JCP.19m12929

Kanekasu, H., Shiraiwa, Y., Taira, S., & Watanabe, H. (2024). Primiparas’ prenatal depressive symptoms, anxiety, and salivary oxytocin level predict early postnatal maternal–infant bonding: a Japanese longitudinal study. Archives of Women's Mental Health, 27(4), 649-658. https://doi.org/10.1007/s00737-024-01441-5 DOI: https://doi.org/10.1007/s00737-024-01441-5

Laili, N., et al. (2024). Oxytocin levels and postpartum depression symptoms among Indonesian mothers. African Journal of Biological Science 6 (Si2), 724-729.

Nagahashi-Araki, A., (2017). Oxytocin mediates a calming effect on postpartum mood in primiparous mothers. Breastfeeding Medicine, 12(2). https://doi.org/10.1089/bfm.2016.0052 DOI: https://doi.org/10.1089/bfm.2016.0052

Oon-arom, A., Suradom, C., & Srichairatanakool, S. (2022). Serum oxytocin and corticotropin‐releasing hormone in the third trimester predicting postpartum depression in Thai women. Asian Journal of Psychiatry, 80(Suppl 20), 103392. https://doi.org/10.1016/j.ajp.2022.103392 DOI: https://doi.org/10.1016/j.ajp.2022.103392

Rawashdeh, H., Alalwani, Z., Sindiani, A., Alodetalah, R., & Alqudah, M. (2021). The role of third trimester oxytocin level in predicting postpartum depression symptoms among Jordanian mothers. International Journal of Gynecology & Obstetrics, 159(1), 123–130. https://doi.org/10.1155/2022/7474121 DOI: https://doi.org/10.21203/rs.3.rs-172460/v1

Shishido, E., Ogi, Y., & Horiuchi, S. (2023). Oxytocin changes in women with emergency cesarean section: Association with maternal blues by delivery mode. Heliyon, 9(4), e15405. https://doi.org/10.1016/j.heliyon.2023.e15405 DOI: https://doi.org/10.1016/j.heliyon.2023.e15405

Shishido, E., Shuo, T., Shinohara, K., & Horiuchi, S. (2021). Effects of epidural anesthesia on postpartum maternity blues and fatigue and its relation to changes in oxytocin. Japan Journal of Nursing Science, 18(3), e12406. DOI: https://doi.org/10.1111/jjns.12406

Shorey, S., Asurlekar, A. R., Chua, J. S., & Lim, L. H. K. (2023). Influence of oxytocin on parenting behaviors and parent–child bonding: a systematic review. Developmental Psychobiology, 65(2), e22359. DOI: https://doi.org/10.1002/dev.22359

Weinstein, S. R., Erickson, E. N., Molina, R., & Bell, A. F. (2023). Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review. Comprehensive Psychoneuroendocrinology, 16. https://doi.org/10.1016/j.cpnec.2023.100209 DOI: https://doi.org/10.1016/j.cpnec.2023.100209

Yakup, K. A. M., David, L. D., Pudzi, N. A., Shukor, A. H. A., Sabri, M. Q. M., & Dahlan, A. (2022). Exploring Visual Perception Among Children With Developmental Disability: A Scoping Review. Malaysian Journal of Medicine & Health Sciences, 18.

Yu, X., Zhang, W., & Gao, Y. (2024). Investigation and analysis of emotional state and oxytocin level in patients with postpartum depression. Actas Españolas de Psiquiatría, 52(3), 204–210. https://doi.org/10.62641/aep.v52i3.1627 DOI: https://doi.org/10.62641/aep.v52i3.1627

Yu, Y., Liang, H. F., Chen, J., Li, Z. B., Han, Y. S., Chen, J. X., & Li, J. C. (2021). Postpartum depression: Current status and possible identification using biomarkers. Frontiers in Psychiatry, 12, 620371. DOI: https://doi.org/10.3389/fpsyt.2021.620371

Zhao, X. H., & Zhang, Z. H. (2020). Risk factors for postpartum depression: An evidence-based systematic review of systematic reviews and meta-analyses. Asian journal of psychiatry, 53, 102353. DOI: https://doi.org/10.1016/j.ajp.2020.102353

Zoubovsky, S. P., Hoseus, S., Tumukuntala, S., Schulkin, J. O., Williams, M. T., Vorhees, C. V., & Muglia, L. J. (2020). Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression. Translational Psychiatry, 10(1), 6. DOI: https://doi.org/10.1038/s41398-020-0704-2